This information webinar on the 2026 Joint Transnational Call for Proposals is scheduled for 16 December 2025, 15:00–17:00 CET, focusing on resolving unsolved rare genetic and non‑genetic diseases.
This online webinar will introduce the forthcoming 2026 Joint Transnational Call, “Resolving unsolved cases in rare genetic and non‑genetic diseases”. Participants will hear how the call fits within ERDERA’s Funding workstream and how it will support multinational, interdisciplinary projects focused on delivering diagnostic clarity for people living with a rare disease.
We will outline scope, eligibility, timelines and expectations for patient partnership, and signpost where to find national/regional rules and submission guidance.
The session will also cover how ERDERA’s services and networks can strengthen proposals. A short presentation will introduce ERDERA and its hubs, including how the Clinical Research Network enhances diagnostic pathways and trial readiness by linking expert centres and harmonising procedures, the Data Services Hub supports secure, FAIR data sharing and analysis, and the Expertise Services Hub offers practical guidance on study design, regulatory pathways and methods. A dedicated segment on patient engagement will explain how meaningful PPIE is embedded throughout the call—from co‑defining priorities to governance and reporting—so that projects respond to patient‑need and drive real‑world impact.
Website:
Preliminary agenda:
Expertise support services: how to access methodological, regulatory and clinical guidance to strengthen your consortium and proposal.On 10 December 2025, ERDERA will launch its 2026 Joint Transnational Call, “Resolving unsolved cases in rare genetic and non‑genetic diseases”.
Presentation of ERDERA: who we are and how our hubs support research across Europe;
JTC 2026 introduction: scope, eligibility, timelines and evaluation;
Patient engagement in research: expectations, good practice and support for PPIE;
The call will welcome proposals focused on providing diagnostic clarity in unsolved rare genetic and non‑genetic diseases.
This call’s pre‑announcement is available below, and it describes the forthcoming opportunity for multinational research teams to apply and will be updated with the full call when it launches.
An information webinar for potential applicants will take place on 16 December, 15:00–17:00 CET. Register for the webinar through this link.
Call Topic
The goal of this call is to solve Undiagnosed Rare Genetic diseases and to address complex, multifactorial Rare Non-Genetic diseases by identifying causative variants in patients with no molecular diagnosis after prior genetic or genomic testing and providing diagnostic clarity for conditions of unknown or mixed pathogenesis.
Suggested focus areas are:
- Functional validation to classify Variants of Uncertain Significance (VUS) and increase the diversity of functional genomics research, or validation of candidate VUS to improve outcomes for a broader range of patients using in silico, in vitro or animal model systems (e.g. CRISPR modified cells, iPSCs, organoids, etc.);
- Use of multi-omics or integrative methods (e.g. transcriptomics, epigenomics, etc.) to resolve ambiguous or complex variants;
- New tools/methodologies not yet validated in clinical settings, including biostatistics, advanced bioinformatics, and mathematics approaches (e.g. variant effect predictors, Artificial Intelligence (AI)-based annotation platforms, etc.);
- Systems biology and disease mechanism modelling;
- Integration of clinical, environmental, lifestyle, and sensor-derived data;
- Development of knowledge graphs or disease maps to link phenotypic and mechanistic insights;
- Use of advanced AI and modelling tools (graph ML, probabilistic causal models).
KONTAKTNÁ OSOBA
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